منابع مشابه
Evidence for the clonal abortion theory of B-lymphocyte tolerance
This paper deals with the behavior of adult mouse bone marrow cells placed in tissue culture with or without antigen, and subsequently assessed for immune competence after adoptive transfer into lethally X-irradiated, syngeneic hosts. Attention was focussed on B lymphocytes through using hapten human gamma globulin (HGG) preparations as putative tolerogens in tissue culture, the T-cell-independ...
متن کاملSites of B Lymphocyte Selection, Activation, and Tolerance in Spleen
T he immune system appears to be rigid, restricting one lymphocyte to make one antibody (1) and the peripheral B cell pool to a constant number (10 8 in mice) (2– 4). To make a rapid immune response to an unlimited number of antigens at any anatomical site, it has developed at least three major strategies: (a) continuous production of 2 ϫ 10 7 lymphocytes/d from bone marrow (mice; 5), displayin...
متن کاملDisturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus.
In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia was identified that affected CD19(+)/CD27(-) naive B cells more than CD19(+)/CD27(+) memory B cells, leading to a relative predominance of CD27-expressing peripheral B cells. CD27(high)/CD38(+)/CD19(dim)/surface Ig(low)/CD20(-)/CD138(+) plasma cells were found at high frequencies in active but not inactive SL...
متن کاملBAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development
B-lymphocyte homeostasis depends on exogenous signals for survival during development and in immune responses to invading pathogens. These signals are continually provided by either tonic or antigen-mediated BCR signals and other trophic factors. B-cell-activating factor (BAFF) has emerged as a key growth factor for B lymphocytes. Through its interaction with a TNF-R family member, BAFF-R or BR...
متن کاملCutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction.
T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the func...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2004
ISSN: 0022-9717,1880-1293
DOI: 10.2302/kjm.53.151